Do Dogs Really Need Prozac? Natural Alternatives for Treating Anxiety in 2025

Prozac use in dogs has skyrocketed by nearly 10x over the past decade, as more veterinarians prescribe fluoxetine to treat anxiety and behavioral issues in pets. But is this really the only option? As pet parents seek gentler, holistic care, natural remedies are gaining momentum — and in many cases, proving highly effective.

Why Dog Anxiety Is on the Rise in 2025

Just like humans, dogs today face stressors that didn't exist 20 years ago. More time indoors, overstimulation from busy households, prolonged isolation, and even their owner's own anxiety can impact a dog’s emotional well-being. In fact, studies show a significant increase in anxiety-related behaviors in dogs since the COVID-19 pandemic.

A 2023 survey by the American Pet Products Association found that over 67% of dog owners reported behavior changes like restlessness, increased vocalization, or avoidance behaviors — all signs of stress or anxiety. As we humanize pet care more than ever, the demand for emotional support solutions has exploded.

Is Your Dog’s Bed Making Them Anxious?

One often-overlooked factor in canine anxiety is your dog’s bed. Many imported pet beds are manufactured with low-cost chemical treatments — including flame retardants, formaldehyde-based resins, azo dyes, and heavy metal residues. These substances can leach into your dog’s skin through daily contact and contribute to inflammation, allergic responses, and even neurobehavioral changes.

Research shows that chronic low-level chemical exposure can impair hormone regulation and trigger immune responses, which may appear as irritability, restlessness, and sleep disturbances — all symptoms that can be mistaken for or lead to anxiety.

That’s why we recommend switching to dog beds made with OEKO-TEX® certified fabrics. These beds are tested against over 1,000 known harmful chemicals, ensuring your pet is resting on non-toxic materials that support their physical and mental well-being.

If your dog struggles with chronic anxiety, scratching, or frequent skin irritation, upgrading their bedding could be a foundational step in your holistic treatment plan.

The Link Between Anxiety, Gut Health, and Diet

New research into the gut-brain axis reveals that the bacteria in your dog’s digestive system can directly impact their emotional well-being. A balanced microbiome produces neurotransmitters like serotonin and GABA — both vital for mood regulation. An imbalance caused by poor-quality food, antibiotics, or stress can trigger anxiety and even aggression.

To support a healthy gut-brain connection, focus on feeding high-quality, whole food diets that avoid fillers and artificial preservatives. Consider adding:

• Probiotics: Look for formulas with Lactobacillus and Bifidobacterium species
• Prebiotics: Chicory root, pumpkin, and green bananas help feed beneficial bacteria
• Digestive enzymes: Especially important for senior dogs or those with GI issues

The Science Behind Canine Stress and Neurochemistry

Dog anxiety isn't just “in their head.” It's a physiological response governed by their nervous and endocrine systems. The hypothalamic-pituitary-adrenal (HPA) axis, responsible for managing stress responses, becomes hyperactive under chronic anxiety — elevating cortisol and affecting mood, digestion, and even immune health.

According to a 2021 study in Frontiers in Veterinary Science, dogs diagnosed with separation anxiety had significantly elevated cortisol and ACTH levels. These biochemical markers reinforce the need for long-term solutions that work with the body, not just suppress symptoms.

Supplement Dosage Table for Common Natural Remedies

What Experts Are Saying

Dr. Judy Morgan, DVM and holistic pet advocate, reminds pet parents: “Anxiety in dogs is almost always a symptom of imbalance — emotional, physical, or environmental. Nutrition, routine, and trust are your foundation. Herbs and supplements are tools, not magic bullets.”

She emphasizes individualized care: “There is no ‘one size fits all’ protocol. One dog may thrive on L-theanine and exercise. Another may need a calming vest, massage therapy, and a probiotic boost. Tune in, observe, and adjust.”

In 2024, the American Holistic Veterinary Medical Association reported a 34% increase in successful anxiety case outcomes when behavior therapy was paired with natural supplementation versus pharmaceuticals alone.

Expanded Guide to Natural Remedies

Chamomile

Chamomile works by binding to the same brain receptors as benzodiazepines, but without their addictive properties. It’s safe for most dogs when brewed as a tea and added to food or water. Start with 1 teaspoon of cooled tea per 10 lbs of body weight.

Valerian Root

Valerian acts as a mild sedative and muscle relaxant. Studies show it can lower cortisol levels in both humans and canines. Administer ¼ tsp dried root or follow vet-formulated dosages via tinctures. It’s best used situationally — before travel or stressful events.

CBD Oil

CBD oil interacts with the endocannabinoid system to help regulate stress. Choose organic, THC-free formulations. Start with 0.25 mg per pound of body weight and increase gradually. A 2020 study in Animals showed CBD significantly reduced anxiety scores in shelter dogs after 14 days.

L-theanine

This amino acid boosts dopamine and serotonin without sedation. It’s especially useful for dogs prone to thunderstorm phobia or separation anxiety. Vet-approved chews often contain 25–100 mg per serving.

Ashwagandha

A powerful adaptogen that helps the body adapt to stress. It balances cortisol and supports the adrenal glands. Typical dose: 100–250 mg daily for small to medium dogs.

Real-Life Success Stories: More Holistic Wins

Luna, a Border Collie mix struggled with leash reactivity. Her owner introduced a high-probiotic diet, used L-theanine daily, and switched to a harness with enrichment games. “She’s like a different dog in 6 weeks,” they reported.

Jackson, a high-strung Jack Russell was weaned off Prozac over 2 months and now relies on a rotation of valerian and ashwagandha with supervised social exposure and crate rest. His nighttime pacing stopped within 3 weeks.

Weekly Wellness Routine for Anxious Dogs

Consistency helps dogs thrive. Here’s a sample week to combine natural solutions with structure:

• Daily: Morning walks, scheduled feeding, calming music during alone time, calming chew supplement
• Monday: 20-minute puzzle session after dinner
• Tuesday: Scent walk through a new area
• Wednesday: Chamomile tea and cuddle session with massage
• Thursday: Crate games to build comfort with alone time
• Friday: Add salmon oil for omega-3 brain support
• Saturday: Longer play outing or social visit
• Sunday: Quiet time, vet-approved aromatherapy, and reflection

Combining a consistent routine with safe, toxin-free sleeping quarters helps eliminate hidden environmental triggers where your dog may be resting up to 18 hours a day.

Vet-Recommended Natural Supplement Brands

• TheraPetixx Calm Support – Herbal blend with L-theanine, ashwagandha, and B vitamins
• VetriScience Composure Pro – Trusted for dogs with stress behaviors
• ElleVet CBD Soft Chews – Third-party tested, full-spectrum CBD from Cornell research
• Adored Beast Gut Soothe – Combines probiotics and anti-inflammatory herbs

Q&A: Common Reader Questions

Q: How long do natural remedies take to work?
A: Most herbal remedies begin to show effects within 2–4 weeks. Consistency and correct dosing are key.

Q: Can I use CBD or valerian root alongside Prozac?
A: Always consult your veterinarian before combining treatments. Some remedies may interact with pharmaceuticals.

Q: Are there breed-specific responses to natural remedies?
A: Yes. Sighthounds (e.g., Greyhounds) can be sensitive to sedatives. Always tailor to your dog’s size and breed.

Final Thoughts

Natural remedies for anxiety in dogs aren’t just a trend — they’re a reflection of how modern pet parents want to nurture health from the inside out. By combining science, routine, and nature’s pharmacy, we can support our pups emotionally and physically without over-relying on pharmaceuticals.

If you’re interested in a full natural health approach for your dog, don’t forget to check out our e-book:

10 Essential Vitamins & Herbal Remedies Your Dog Needs Now

About the Author

Go Doggie Style is more than just a dog boutique — it’s a passion project by Dr. Patria Smith, a Doctor of Pharmacy, Board Certified Pharmacotherapy Specialist, Entrepreneur, wife, mother of 4 beautiful children and a proud dog mom. Founded in 2019, our blog blends professional insight, scientific accuracy, and a deep love for dogs to help pet parents give their pups the healthiest, happiest life possible.